Our news

The 7th Targeted Protein Degradation & Induced Proximity Summit span foundational research and discovery, through to IND-filing and clinical trials. It discusses opportunities and challenges the TPD & Induced Proximity field must address to expand the target space and facilitate the discovery and development of therapeutically relevant degraders, blockers, stabilizers and inducers of protein-protein interactions.

We support your research with cutting-edge technologies. Our Y2H-based screening platforms help understanding biological processes triggered by small molecules:

• Identify direct protein interaction partners to decipher mechanisms of action

• Discover protein complexes induced by Molecular Glues or PROTACs like molecules

• Choose from over 135 highly complex cDNA libraries

• Explore our human E3 ligases library

Come and meet us at #Microbes2023, the microbiology conference in France. We are so proud presenting our Y2H and Nanobody technology platforms.

Join our colleague Abarna Lingeswaran PhD at her poster “Exhaustive Protein Interaction Mapping: A Powerful Tool for Understanding Host-Pathogen Interactions and Biological Pathways in Pathogens” on 5th Oct between 5pm15-6pm to explore our #ProteinInteraction discovery technologies and our extensive library collection.

Discovery on Target (DOT) is a conference on novel drug targets and technologies, as well as target validation strategies for the discovery of novel therapeutic agents. Hybrigenics Services provides research support with cutting-edge technologies in the field of Degraders, Molecular Glues, Induced Proximity and Target Identification Strategies.

• Our Y2H-based platforms help understanding biological processes triggered by small molecules:

• Identify direct protein interaction partners to decipher mechanisms of action

• Discover protein complexes induced by Molecular Glues or PROTACs like molecules

• Our Hybribody platform is an animal free technology to select and validate single domain antibodies

We are very much looking forward to meeting long-time colleagues, sponsoring great scientific exchange and presenting our Nanobody Selection platform at Single-Domain Antibodies Conference at the Institute Pasteur, from September 18-20 in Paris.

Meet our CEO Jean-Christophe Rain and colleague Imenne Boubakour PhD to develop your #VHH strategy or #optimize your current sdAB. Don’t miss your chance to discuss with our experts one on one.

We are very pleased to congratulate Prof. Schuurink and Prof. Kant from Amsterdam University for their publication on the immunity of tomato to whiteflies.

Our team identified and confirmed the interaction of the whitefly G4 effector protein with tomato target proteins like MIPDB141 and RSP1. The researchers provide more insight on how whiteflies are able to hijack the physiology of the plant. The identified host targets may be interesting for further development of resistance against whiteflies.

If you are interested in finding your favorite protein’s interaction partners, please contact us to get more information about our Yeast 2-Hybrid Services.

We send our heartfelt congratulation to Prof. Frédéric Darios and his team at Sorbonne Université, Paris Brain Institute, ICM and are so proud to have supported their work to gain insights into how spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1. We are very happy to see that our Y2H technology could support your neuroscience research.

If you are interested in finding your favorite protein-protein interaction partners, please contact us to know more about our yeast-two hybrid services.

Our hearthfelt congrats to Prof. Luca L Fava and his colleagues at CIBIO, University of Trento as well as in London and Baltimore. We supported their  research investigating DNA repair and p53-mediated stress response with our Y2H technology platform. They gained insights into how PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability.

If you are interested in finding your favorite protein-protein interaction partners, check out our yeast-two hybrid solutions.

Come and meet us during four exciting days of inspiring Immunology Research with international keynote and plenary speakers from #France and #Germany. #sfidgfi2023

We are so proud to be a sponsor of this cutting-edge conference presenting  our Y2H and Nanobody technology, being hosted by the Société Française d'Immunologie and Deutsche Gesellschaft für Immunologie. Join our colleagues Michael Mulot PhD and Susanne Reichinnek PhD to explore our portfolio for Protein Interaction Discovery as well our extensive library collection to boost your project with new insights.

Let's connect and meet one on one with our experts.

We send our heartfelt congratulation to Prof.

Patrick Giguere and his team at University of Ottowa and are so proud to have supported their development of a V5-tag-directed nanobody with our #VHH technology platform. This nanobody works as an intracellular biosensor of GPCR signaling and is an incredible versatile tool for live-cell imaging and welcomed adaptation to cellular assays probing #PPIs. 

Congratulations! We are delighted to have supported so many projects with our Protein Interactions and Nanobody technology platforms, in so many life science fields  #cancerresearch #immonology #micobiology #plantscience #neuroscience #hostpathogen and all animal-free.

We always strive to be the best partner to make breakthroughs possible and are looking forward supporting the scientific community to achieve their goals, advance their knowledge about protein interactions & make new discoveries.

Congratulations to Slimane Ait-Si-Ali lab  and his colleagues for their paper “The Cytoplasmic Fraction of the Histone Lysine Methyltransferase Setdb1 is Essential for Embryonic Stem Cells” in iScience. We are very happy to see that our Y2H technology could support your  stem cell research and gene expression.

If you are interested in finding your favorite protein-protein interaction partners feel free to contact us to know more about our yeast-two hybrid services.

Meet with our colleague Marie-Edith Gourdel at the conference on Next-Generation Degraders & Glues in London and pass by her poster P20 to discuss your Targeted Protein Degradation projects and our technology platforms. With our 25 years’ experience in Protein-Interaction discovery with our yeast-two-hybrid based technologies, we are your partner-of-choice to identify or work with E3 ligases, Ubiquitin,  and Molecular Glues.

Congratulations to Christina Manner and her colleagues in the lab of Urs Jenal on their paper “A genetic switch controls Pseudomonas aeruginosa surface colonization” in nature Microbiology. We are delighted that the identification of the interaction between HecE and the phosphodiesterase BifA helped to better understand the c-di-GMP control and biofilm formation in this human pathogen.

Join our colleague Brent Passer at the BIO International in Boston presenting our synthetic nanobody capabilities, drug target discovery and drug target deconvolution and our Protein Interaction Platform.

Congratulations to Chiu-Yueh Hung  and his colleagues in the lab of  Jiahua Xie for their paper “A Rapid Alkalinization Factor-like Peptide EaF82 Impairs Tapetum Degeneration during Pollen Development through Induced ATP Deficiency” in Cells 2023. We are very happy to have supported with our Y2H screening service and 1-by-1 direct interaction assays.

On recrute un(e) Technicien(ne) supérieur(e) de Laboratoire en CDI pour notre plateforme de Double Hybride #Y2H #DNA #PCR #Sequence #Microbiology.

Merci de partager autour de vous !

Congratulations to Karim Taouis  and colleagues in the lab of François Lallemand for their paper “WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer” in Cancer Gene Therapy 2023. We are very happy to have supported your research on tumor suppressor gene WWOX  with our Y2H screening service.

You are interested in nanobodies for your research but animal-free ?

Join our CEO Jean-Christophe Rain at #NeuroFrance 2023 in Lyon to learn about our Discovery and Optimization Platform and discuss your nanobody projects. 

Join our colleague Brent Passer at the Annual PEGS Boston Conference presenting our synthetic nanobody capabilities for drug discovery and animal-free antibodies. 

Are you working on Nanobodies, in Drug discovery or Protein Protein Interactions? Meet our colleague Michael Mulot, PhD at Biomed Israel and discuss our technologie platforms and your projects ideas.

Congratulations to Marta A. Inchingolo  and her colleagues in the lab of  Joseph A. Curran for their paper “TP53BP1, a dual-coding gene, uses promoter switching and translational reinitiation to express a smORF protein” in iScience 2023. We are very happy to have supported with our Y2H screening service.

Are you looking for an innovative partner to boost your R&D in Protein-Interaction Discovery, Molecular Glues, E3 ligases, Drug Target Validation and Naznobodies? Contact our colleague Imenne Boubakour and enjoy BioTrinity 2023, London,

Discover our new Pisum sativum leaf and stem library and find new interaction targets for your projects in 2023.

Whether you work on basic plant biology or crop sciences, investigate host-pathogen interactions or new bioactive molecules, we support you in fostering innovation in your scientific research. 

Join our colleagues Abarna Lingeswaran Ph.D. and Susanne Reichinnek Ph.D. at booth CH21, 2-4th November at the congress Center in Basel. presenting our synthetic nanobody capabilities for tauopathies. We present a case-study identifying intrabodies to prevent Tau protein aggregation linked to Alzheimer's diseases and various tauopathies. 

Congratulations to Lisa Baumgartner, Julius Brennecke and their colleagues for their recent publication “The Drosophila ZAD zinc finger protein Kipferl guides Rhino to piRNA clusters” in eLife. We are amazed by their work showing the existence of sequence-specific factors in piRNA biogenesis and happy to have supported their search for interaction partner of Rhino.

We are pleased to sponsor the outstanding meeting Cell la vie 2 ! at the Pasteur Institute in Paris from 21st to 23rd September. Take this opportunity to meet Jean-Christophe Rain, our CEO,  and Imenne Boubakour (BD) to discuss about your protein-protein interaction projects. #CellLaVie2022

Enjoy the Meeting ! 

Congrats to Laurence Levy and their colleagues for their publication Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase. in Mol. Cell. Proteomics 2021. To study the targets of the Arkadia E3 ligase, the authors immunoprecipitated ubiquinated proteins using the Ubiquitin Selector Nanobody, which has been formerly selected by Hybrigenics Services to recognize all ubiquitin chains and monoubiquitylation. This nanobody approach proved to be powerful, as it enabled the identification of 52 substrates for Arkadia. The purified Ubiquitin Selector nanobody is now available for purchase at NanoTag Biotechnologies.

Congratulations to the group of Mohan K. Balasubramanian for their recent publication “mNG-tagged fusion proteins and nanobodies to visualize tropomyosins in yeast and mammalian cells” in J Cell Sci.. We are very happy to see that our Nanobody technology platform could support your  tropomyosins in yeast toolbox.

If you are interested in finding VHh aginst your favorite antigen feel free to contact us to know more about our Naobody services.

Hybrigenics recrute un(e) technicien(e) de laboratoire pour sa plateforme d’interactions protéiques pour notre site basé au Genopole.

We are wholeheartedly sponsoring the ToxoXVI bringing international researchers together and look forward to exchange about projects and support strategies in the Host-Pathogen Molecular Research.

Our Y2H-based platform offers support for the discovery of protein interactions with DNA, RNA and small molecules as well as protein detection with nanobodies.

Come and meet us!

Organized by the French Society of Virology (SFV), 'Les Journées Francophones de Virologie' is a national event welcoming 400 researchers, engineers, technicians, pharmacists and interested parties. In our poster we will present details of the SARS-CoV-2 virus's biology and interactions with its human host.

We thus used our high-throughput platform, which allows exhaustive and reproducible yeast two-hybrid screens, to establish a protein interaction map (PIM) between 29 proteins or protein fragments of SARS-CoV- 2 and proteins from a human lung cell bank. Our PIM links 780 CDS through 979 protein interactions, while delineating the interaction domains providing a better understanding of the biology of SARS-CoV-2. Our map will help pave the way for the identification of new targets of therapeutic interest and other virus infections.

Congratulations to Michael E. Konkel and his colleagues for their paper “The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry” in Nat Commun. We are very happy to see that the Y2H screen with CiaD was useful for their research.

We are looking forward handling to new projects with our customers.

If you are interested in finding your favorite protein partners feel free to contact us to know more about our yeast two hybrid services.

Congratulations to Saskia A. Hogenhout and her colleagues for their paper “Parasite co-opts a ubiquitin receptor to induce a plethora of developmental changes” in Cell 2021. We are very happy to see that the Y2H screen with SAP05 was useful for their research.

If you are interested in finding your favorite protein partners feel free to contact us to know more about our yeast two hybrid services.

Hybrigenics services is participating to the Immunoterapies and innovations for infectious diseases 2020, from December 9th to 10th, 2020.

This meeting aims to foster interactions between pharmaceutical industries, research labs, service providers, technology developers, and clinicians, thereby contributing to the development of innovative strategies against infectious diseases in a multidisciplinary approach.

Dr. Jean-Christophe Rain, CEO, will attend this event and give a talk titled: “SARS-CoV-2 : From Synthetic Nanobodies for flash riposte to exhaustive host-pathogen protein interaction mapping for deep knowledge”

Feel free to Contact us to arrange a meeting.

He will be discussing the ""Selection and optimization of nanobodies against BMPR2"" and looks forward to your questions.

We are delighted to announce that Hybrigenics Services has smoothly moved its labs and offices to the Genopole biocluster, located south of Paris. Genopole is France’s leading biocluster, regrouping 96 biotech companies, 16 academic research labs and 20 shared technology platforms.

We were proud to present our services at the Welcome Session on October 3rd. We look forward to benefiting from this highly innovative and stimulating environment to better serve our clients and partners across the world.

And we can’t wait to set-up new collaborations locally!