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Neuroscience - Cell Biology

Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton

Victor Macarrón-Palacios, Jasmine Hubrich, Maria Augusta do Rego Barros Fernandes Lima, Nicole G. Metzendorf, Simon Kneilmann, Marleen Trapp, Claudio Acuna, Annarita Patrizi, Elisa D’Este, Manfred W. Kilimann

(2025) Science Advances 7 Mar 2025 Vol 11, Issue 10

Cell Biology - Immunology

Optimal Stapling of a Helical Peptide-Foldamer Hybrid Using a C-terminal 4-Mercaptoproline Enhances Protein Surface Recognition and Cellular Activity

Maxime Neuville, Mathieu Bourgeais, Jérémie Buratto, Claire Saragaglia, Bo Li, Isabel Galeano-Otero, Laura Mauran, Laetitia Varajao, Sébastien R. Goudreau, Brice Kauffmann, Emmanuelle Thinon, Morgane Pasco, Abdel-Majid Khatib, and Gilles Guichard

(2025) Chem. Eur. J. 2025, e202403330

Immunology - Cell Biology

HMCN1 variants aggravate epidermolysis bullosa simplex phenotype

Shir Bergson , Ofer Sarig , Moshe Giladi , Janan Mohamad , Mariana Mogezel-Salem , Karina Smorodinsky-Atias , Ofir Sade , Bar Manori , Sari Assaf , Kiril Malovitski , Yarden Feller , Mor Pavlovsky , Stefan Hainzl , Thomas Kocher , Julia I. Hummel , Noy Eretz Kdosha , Lubna Gazi Khair , Roland Zauner , Josefina Pinon Hofbauer , Ruby Shalom-Feuerstein , Verena Wally , Ulrich Koller , Liat Samuelov , Yoni Haitin , Uri Ashery , Rotem Rubinstein

(2025) J Exp Med (2025) 222 (5): e20240827.

Molecular Biology

Cell-Permeable Peptide Inhibitors of the p53-hDM2 Interaction via Foldamer Helix Mimicry and Bis-Thioether Stapling

Maxime Neuville Maxime Neuville Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, F-33607 Pessac, France IMMUPHARMA BIMaxime Neuville, Mathieu Bourgeais, Bo Li, Laetitia Varajao, François Hallé, Sébastien R. Goudreau, Emmanuelle Thi, 0non, Morgane Pasco, Abdel-Majid Khatib, Gilles Guichard

(2024) ACS Journal of Medicinal Chemistry doi.org/10.1021/acs.jmedchem.4c01762

Cell Biology - Molecular Biology

Guanidinium-Stapled Helical Peptides for Targeting Protein-Protein Interactions

Camille Perdriau, Anaïs Luton, Katharina Zimmeter, Maxime Neuville, Claire Saragaglia, Carole Peluso-Iltis, Judit Osz, Brice Kauffmann, Gavin W Collie, Natacha Rochel, Gilles Guichard, Morgane Pasco

(2024) GDHc Journal of german Chemical Society, https://doi.org/10.1002/anie.202416348

Development - Molecular Biology

CCDC28A deficiency causes head-tail coupling defects and immotility in murine spermatozoa

Nena Stojanovic, Rosario Ortiz Hernández, Nayeli Torres Ramírez, Olga Margarita Echeverría Martínez, Abrahan Hernández Hernández & Hiroki Shibuya

(2024) Nature, Scientific Reports volume 14, Article number: 26808 https://doi.org/10.1038/s41598-024-78453-9

Metabolism - Molecular Biology

GCKIII Kinases Control Hepatocellular Lipid Homeostasis via Shared Mode of Action

Emmelie Cansby, Mara Caputo, Emma Andersson, Rasool Saghaleyni, Marcus Henricsson, Ying Xia, Bernice Asiedu, Matthias Blüher, L. Thomas Svensson, Andrew J. Hoy, Margit Mahlapuu

(2024) Journal of Lipid Research, doi: https://doi.org/10.1016/ j.jlr.2024.100669.

Molecular Biology - Metabolism

HNF1β bookmarking involves Topoisomerase 1 activation and DNA topology relaxation in mitotic chromatin

Alessia Bagattin, Salvina Laura Tammaccaro, Magali Chiral, Munevver Parla Makinistoglu ∙ Nicolas Zimmermann ∙ Jonathan Lerner, Serge Garbay ∙ Nicolas Kuperwasser, Marco Pontoglio

(2024) Cell Reports, Volume 43, Issue 10114805October 22, doi.org/10.1016/j.celrep.2024.114805

Molecular Biology - Cell Biology

SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane abundance in the endolymphatic sac

Hyun Jae Lee, Cristina Fenollar-Ferrer, Kevin Isgrig, Ya-Xian Wang, Kerstin Valente, Juleh Eide, Keiji Honda, Wade W. Chien, Ronald S. Petralia, Lijin Dong, Thomas B. Friedman, Juan S. Bonifacino , Andrew J. Griffith, and Isabelle Roux

(2024) Science Advances 9 Oct 2024 Vol 10, Issue 41 DOI: 10.1126/sciadv.adm8663

Nanobodies

NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity

Susan Kilgas, Aleem Syed, Patrick Toolan-Kerr, Michelle L. Swift, Shrabasti Roychoudhury, Aniruddha Sarkar, Sarah Wilkins, Mikayla Quigley, Anna R. Poetsch, Maria Victoria Botuyan, Gaofeng Cui, Georges Mer, Jernej Ule, Pascal Drané & Dipanjan Chowdhury

(2024) Nature Communications volume 15, Article number: 8438, DOI: 10.1038/s41467-024-52862-w

Microbiology - Molecular Biology

Anaplasma phagocytophilum invasin AipA interacts with CD13 to elicit Src kinase signaling that promotes infection

Mary Clark H. Lind, Waheeda A. Naimi, Travis J. Chiarelli, Tavis Sparrer, Mallika Ghosh, Linda Shapiro, Jason A. Carlyon

(2024) Host-Microbial Interactions Research Article 26 September, DOI: https://doi.org/10.1128/mbio.01561-24

Microbiology - Molecular Biology

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

Haley E. Adcox, Jason R. Hunt, Paige E. Allen, Thomas E. Siff, Kyle G. Rodino, Andrew K. Ottens & Jason A. Carlyon

(2024) Nature Communications volume 15, Article number: 8069